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Background
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SH-5 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines that contain high levels of active Akt and depend upon Akt for survival. Synonyms: D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2- methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
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