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  • 產(chǎn)品名稱：Goatanti-Mouse(Murine)IgG1Antibody(HRP)

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簡單介紹：
Goatanti-Mouse(Murine)IgG1Antibody(HRP)
詳情介紹：
Immunogen Mouse IgG1 paraproteins.
Isotype IgG
Purification Affinity Chromatography
Background Immunoglobulin G (IgG), is one of the most abundant protein in human serum with normal levels between 8-17?mg/mL in ***** blood. IgG is important for our defence against microorganisms and the molecules are produced by B-lymphocytes as a part of our adaptive immune response. The IgG molecule has two separate functions, to bind to the pathogen that elicited the response and to recruit other cells and molecules to destroy the antigen. The variability of the IgG pool is generated by somatic recombination and the number of specificities in an individual at a given time point is estimated to be 10e11 variants. Of the four human IgG subclass heavy chain (IGHG) genes, three, IGHG1, IGHG2 and IGHG3, have allelic forms which encode antigenic determinants called G1m, G2m and G3m allotypes for markers of the IgG1, IgG2 and IgG3?Molecules.Synonyms: Mouse Immunoglobulin G1
Research Area Secondary Antibodies
Application Notes ELISA: 1/4000-1/8000. Western Blot. Immunohistochemistry on Frozen and Paraffin Sections.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS,?pH 7.4, 0.01?% Thiomersal, 50?% Glycerol
Preservative Thimerosal (Merthiolate)
Precaution of Use Biohazard Informations: This product contains thimerosal which is hazardous.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Centrifuge product if not completely clear after standing at room temperature.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.
Background publications Bagai, Pawar: "A blood stage fraction of Plasmodium berghei induces protective and long lasting immune response in BALB/c mice." in: Parasitology international, Vol. 62, Issue 3, pp. 329-36, 2013 (PubMed).

Young, Ibuki, Nakamori, Fan, Mine: "Soy-derived di- and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis." in: The Journal of nutrition, Vol. 142, Issue 2, pp. 363-8, 2012 (PubMed).

Zuo, Quinn, Tamblyn, Thomas, Feederle, Delecluse, Hislop, Rowe et al.: "The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the ..." in: Journal of virology, Vol. 85, Issue 4, pp. 1604-14, 2011 (PubMed).

Knipping, McNeal, Crienen, van Amerongen, Garssen, Vant Land: "A gastrointestinal rotavirus infection mouse model for immune modulation studies." in: Virology journal, Vol. 8, pp. 109, 2011 (PubMed).

Croft, Shannon-Lowe, Bell, Horst, Kremmer, Ressing, Wiertz, Middeldorp, Rowe, Rickinson, Hislop: "Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle." in: PLoS pathogens, Vol. 5, Issue 6, pp. e1000490, 2009 (PubMed).